Disease severity-related antigenic differences in dengue 2 strains detected by dengue 4 monoclonal antibodies
✍ Scribed by David M. Morens; Scott B. Halstead
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 283 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0146-6615
No coin nor oath required. For personal study only.
✦ Synopsis
Low-passage epidemic 'Thai isolates of dengue 2 (DEN-2) were distinguished on the basis of associated disease severity by detection of virus determinants involved in enhanced macrophage infection when incubated with a panel of monoclonal antibodies derived from a D E N 4 strain associated with grade I1 dengue hemorrhagic fever (DHF). DEN-2 strains associated with DHF typically had multiple determinants that were involved in antibody-dependent enhancement of infection, whereas those associated with uncomplicated disease had few. These data provide further evidence that in epidemic areas where DHF is associated with prior circulation of low-level monotypic antibody, severe dengue disease could represent antibody-enhanced infection of human monocytedmacrophages.