Disease location, anti-Saccharomyces cerevisiae antibody, and NOD2/CARD15 genotype influence the progression of disease behavior in Crohn's disease
β Scribed by Ben R. K. Smith; Ian D. R. Arnott; Hazel E. Drummond; Elaine R. Nimmo; Jack Satsangi
- Book ID
- 110086252
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 120 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1078-0998
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Background: NOD2 is involved in Crohn's disease (CD), but the role of NOD1 remains unclear. Anti-Saccharomyces cerevisiae antibodies (ASCA) are higher in CD patients and some of their relatives. Using family-based analyses we investigated the relationships between NOD2 mutations, NOD1 ΓΎ32656 variant
## Background: Both antibodies to saccharomyces cerevisiae (asca) and carriage of two mutated nod2/card15 alleles are associated with ileal crohn's disease (cd) and complications requiring bowel surgery. we assessed the asca titer as a marker of cd clinical behavior. ## Methods: In a cross-sectio
Background: Antibodies directed against Saccharomyces cerevisiae (ASCA), perinuclear components of neutrophils (pANCA), and porin protein C of Escherichia coli (anti-OmpC) are reported to be associated with disease phenotype and may be of diagnostic importance in inflammatory bowel disease (IBD). Si