Disease activity, severity, and damage in the UK juvenile-onset systemic lupus erythematosus cohort
β Scribed by Louise Watson; Valentina Leone; Clarissa Pilkington; Kjell Tullus; Satyapal Rangaraj; Janet E. McDonagh; Janet Gardner-Medwin; Nick Wilkinson; Phil Riley; Jane Tizard; Kate Armon; Manish D. Sinha; Yiannis Ioannou; Neil Archer; Kathryn Bailey; Joyce Davidson; Eileen M. Baildam; Gavin Cleary; Liza J. McCann; Michael W. Beresford; on behalf of the UK Juvenile-Onset Systemic Lupus Erythematosus Study Group
- Book ID
- 112002704
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 157 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective To assess the healthβrelated quality of life (HRQL) of patients with juvenileβonset systemic lupus erythematosus (JSLE) and its relationship with disease activity and accumulated damage. ## Methods In this crossβsectional study, HRQL was assessed using the Child Health Q
## Abstract ## Objective Accumulation of apoptotic cells may lead to the development of systemic lupus erythematosus (SLE) through a breakdown in immune tolerance. Altered neutrophil apoptosis may contribute to nuclear autoantigen exposure, ultimately leading to autoantibody generation. This study