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Discriminative stimulus properties of mCPP: evidence for a 5-HT2C receptor mode of action

✍ Scribed by J. Gommans; Theo H. Hijzen; Robert A. A. Maes; Berend Olivier

Book ID
105884593
Publisher
Springer
Year
1998
Tongue
English
Weight
246 KB
Volume
137
Category
Article
ISSN
0033-3158

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Rats were trained to discriminate nicotine (0.4 mg/kg SC) from saline in a standard two-bar operant conditioning procedure with food reinforcement. The response to nicotine was dose-related and at the ED50 of 0.14 mg/kg, plasma nicotine concentrations were similar to those reported previously for ci