Discriminative response control byd-amphetamine and related compounds in the rat

✍ Scribed by Catherine N. Jones; Harlan F. Hill; Robert T. Harris

• Publisher: Springer
• Year: 1974
• Tongue: English
• Weight: 553 KB
• Volume: 36
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00422566

✦ Synopsis

Rats were trained to discriminate between two levers utilizing druginduced physiological states as discriminative stimuli. Drug injections were associated with reinforcement of response on one lever and saline was associated with reinforcement on the other lever. At equimolar doses, d-and/-amphetamine but not para-hydroxyamphetamine, functioned effectively as cues. Following training, stimulus generalization between these drugs was evaluated. Transfer of response control was observed between the d-and/-isomers, and between para-hydroxyamphetamine and saline in rats trained to utilize d-or/-amphetamine versus saline as cues. These findings suggest the importance of central pharmacological activity in this type of response control.