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Discrimination by rabbit anti-idiotypic antibodies of two murine IgM monoclonal antibodies directed against lipid A

✍ Scribed by J.J. Cornelissen; T.A.M. Oosterlaken; J. Schellekens; R. Torensma; M. Rozenberg-Arska; C.A. Kraaijeveld; J. Verhoef


Book ID
118901967
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
485 KB
Volume
130
Category
Article
ISSN
0022-1759

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A syngeneic anti-idiotype monoclonal antibody (MAb) (CM-I I) directed against an anti-carcinoembryonic antigen (CEA) murine MAb (NP-4) was evaluated as a second antibody (SA) to promote the rapid clearance of radiolabeled NP-4 from the blood. Initial studies confirmed that CM-I I IgG removed l3Il-NP