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Discrepancy between the initial DNA damage and cell survival after camptothecin treatment in two murine lymphoma L5178Y sublines

✍ Scribed by Iwona Grądzka; Irena Szumiel


Book ID
102788388
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
753 KB
Volume
14
Category
Article
ISSN
0263-6484

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DNA repair, cell cycle progression and c
✍ Iwona Gra̧dzka; Janusz Skierski; Irena Szumiel 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 309 KB

The processes involved in cell response to camptothecin (CPT) were investigated in two sublines of L5178Y (LY) murine lymphoma; LY-R, resistant and LY-S, sensitive to X-irradiation, which are inversely cross-sensitive to the drug. The cells were pulse-treated with 2 mM CPT for 1 h; this resulted in