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Discrepancy between in-vitro and in-vivo inductions of differentiation by retinoids of human acute promyelocytic leukemia cells in relapse

✍ Scribed by Kazumi Sampi; Yoshio Honma; Motoo Hozumi; Masaharu Sakurai

Book ID: 113238376
Publisher: Elsevier Science
Year: 1985
Tongue: English
Weight: 254 KB
Volume: 9
Category: Article
ISSN: 0145-2126
DOI: 10.1016/0145-2126(85)90039-6

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## Abstract We have tested the effect of several bile acids on the proliferation and differentiation of the HL60 human promyelocytic leukemia cell line __in vitro__. Deoxycholate, chenodeoxycholate and lithocholic acid caused dose‐dependent inhibition of cell proliferation and induction of differen