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Discrepancy between bone resorption assayed by urinary excretion of pyridinoline crosslinks and of 3H-tetracycline in the rat

✍ Scribed by Egger, C.D.; Mühlbauer, R.C.; Felix, R.; Fleisch, H.; Delmas, P.D.


Book ID
123484429
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
161 KB
Volume
17
Category
Article
ISSN
0169-6009

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✍ Xiao Qing Li; Cheryl A. Donovan; Leroy Klein 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 718 KB

This report presents a pharmacokinetic model in the rat and rabbit of the direct quantification of mature bone resorption in vivo. This is based on a first-order reaction rate describing the release of [3H]tetracycline from bone. Compared with the previous method, the model has two new means of expr