Venlafaxine: Discrepancy between in vivo
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Jean-Claude Béïque; Claude De Montigny; Pierre Blier; Guy Debonnel
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Article
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1999
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John Wiley and Sons
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English
⚖ 284 KB
Using an in vivo electrophysiological paradigm, venlafaxine and paroxetine displayed similar potency for suppressing the firing activity of dorsal raphe 5-HT neurons (ED 50 : 233 and 211 µg/kg i.v., respectively), while venlafaxine was three times less potent than desipramine (ED 50 : 727 and 241 µg