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Discrepancies between the in Vitro and in Vivo 5-HT and Norepinephrine Re-uptake Blocking Properties of Venlafaxine

✍ Scribed by J.-C. BÉÏQUE; G. DEBONNEL; C. de MONTIGNY; P. BLIER


Book ID
111394201
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
118 KB
Volume
861
Category
Article
ISSN
0890-6564

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Venlafaxine: Discrepancy between in vivo
✍ Jean-Claude Béïque; Claude De Montigny; Pierre Blier; Guy Debonnel 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 284 KB

Using an in vivo electrophysiological paradigm, venlafaxine and paroxetine displayed similar potency for suppressing the firing activity of dorsal raphe 5-HT neurons (ED 50 : 233 and 211 µg/kg i.v., respectively), while venlafaxine was three times less potent than desipramine (ED 50 : 727 and 241 µg