Discovery Tactics To Mitigate Toxicity Risks Due to Reactive Metabolite Formation with 2-(2-Hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3- d ]pyrimidin-4(3 H )-one Derivatives, Potent Calcium-Sensing Receptor Antagonists and Clinical Candidate(s) for the Treatment of Osteoporosis

✍ Scribed by Kalgutkar, Amit S.; Griffith, David A.; Ryder, Tim; Sun, Hao; Miao, Zhuang; Bauman, Jonathan N.; Didiuk, Mary T.; Frederick, Kosea S.; Zhao, Sabrina X.; Prakash, Chandra; Soglia, John R.; Bagley, Scott W.; Bechle, Bruce M.; Kelley, Ryan M.; Dirico, Kenneth; Zawistoski, Michael; Li, Jianke; Oliver, Robert; Guzman-Perez, Angel; Liu, Kevin K. C.; Walker, Daniel P.; Benbow, John W.; Morris, Joel

• Book ID: 120303769
• Publisher: American Chemical Society
• Year: 2010
• Tongue: English
• Weight: 427 KB
• Volume: 23
• Category: Article
• ISSN: 0893-228X
• DOI: 10.1021/tx100137n