✦ LIBER ✦

Discovery, Synthesis, and Characterization of an Orally Bioavailable, Brain Penetrant Inhibitor of Mixed Lineage Kinase 3

✍ Scribed by Goodfellow, Val S.; Loweth, Colin J.; Ravula, Satheesh B.; Wiemann, Torsten; Nguyen, Thong; Xu, Yang; Todd, Daniel E.; Sheppard, David; Pollack, Scott; Polesskaya, Oksana; Marker, Daniel F.; Dewhurst, Stephen; Gelbard, Harris A.

Book ID: 121277713
Publisher: American Chemical Society
Year: 2013
Tongue: English
Weight: 630 KB
Volume: 56
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm401094t

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Discovery and Characterization of ACT-33

Discovery and Characterization of ACT-335827, an Orally Available, Brain Penetrant Orexin Receptor Type 1 Selective Antagonist

✍ Steiner, Michel A.; Gatfield, John; Brisbare-Roch, Catherine; Dietrich, Hendrik; 📂 Article 📅 2013 🏛 John Wiley and Sons 🌐 English ⚖ 342 KB

In vitro and in vivo pharmacokinetic cha

In vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases

✍ Huang, Liyue; Be, Xuhai; Berry, Loren; Moore, Earl; Janosky, Brett; Wells, Mary; 📂 Article 📅 2011 🏛 Informa plc 🌐 English ⚖ 741 KB

Discovery of S-[5-Amino-1-(4-fluoropheny

Discovery of S-[5-Amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an Orally Bioavailable and Highly Selective Inhibitor of p38 Map Kinase

✍ Goldstein, David M.; Alfredson, Tom; Bertrand, Jay; Browner, Michelle F.; Cliffo 📂 Article 📅 2006 🏛 American Chemical Society 🌐 English ⚖ 271 KB

Identification and Characterization of N

Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor

✍ Maira, S.-M.; Pecchi, S.; Huang, A.; Burger, M.; Knapp, M.; Sterker, D.; Schnell 📂 Article 📅 2011 🏛 American Association for Cancer Research 🌐 English ⚖ 727 KB

Potent Quinoxaline-Based Inhibitors of P

Potent Quinoxaline-Based Inhibitors of PDGF Receptor Tyrosine Kinase Activity. Part 2. The Synthesis and Biological Activities of RPR127963 an Orally Bioavailable Inhibitor.

✍ Wei He; et al. et al. 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 65 KB 👁 2 views

Identification and Characterization of 4

Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B Selective N-Methyl-d-Aspartate Receptor Antagonist

✍ Libby, Brian E.; Liverton, Nigel J.; Bednar, Rodney A.; Bednar, Bohumil; Butcher 📂 Article 📅 2007 🏛 American Chemical Society 🌐 English ⚖ 194 KB