Discovery of Trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as Potent, Orally Bioavailable TGR5 (GPBAR1) Agonists: Structure–Activity Relationships, Lead Optimization, and Chronic In Vivo Efficacy

✍ Scribed by Phillips, Dean P.; Gao, Wenqi; Yang, Yang; Zhang, Guobao; Lerario, Isabelle K.; Lau, Thomas L.; Jiang, Jiqing; Wang, Xia; Nguyen, Deborah G.; Bhat, B. Ganesh; Trotter, Carol; Sullivan, Heather; Welzel, Gustav; Landry, Jannine; Chen, Yali; Joseph, Sean B.; Li, Chun; Gordon, W. Perry; Richmond, Wendy; Johnson, Kevin; Bretz, Angela; Bursulaya, Badry; Pan, Shifeng; McNamara, Peter; Seidel, H. Martin

• Book ID: 125527576
• Publisher: American Chemical Society
• Year: 2014
• Tongue: English
• Weight: 751 KB
• Volume: 57
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm401731q