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Discovery of TNF-α as a therapeutic target in rheumatoid arthritis: preclinical and clinical studies

✍ Scribed by Marc Feldmann; Ravinder N Maini


Book ID
114371130
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
212 KB
Volume
69
Category
Article
ISSN
1297-319X

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## Abstract ## Objective Angiotensin II (Ang II) is known to have proinflammatory actions, and Ang II type 1 (AT~1~) receptors are up‐regulated in the rheumatoid synovium, suggesting that this receptor could be a therapeutic target. The purpose of this study was to investigate the antiinflammatory