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Discovery of the First Series of Inhibitors of Human Papillomavirus Type 11: Inhibition of the Assembly of the E1—E2—Origin DNA Complex

✍ Scribed by Christiane Yoakim; William W. Ogilvie; Nathalie Goudreau; Julie Naud; Bruno Hache; Jeff A. O'Meara; Michael G. Cordingley; Jacques Archambault; Peter W. White

Book ID
101948053
Publisher
John Wiley and Sons
Year
2003
Weight
106 KB
Volume
34
Category
Article
ISSN
0931-7597

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Structure Elucidation of the First Inhib
Structure Elucidation of the First Inhibitors of Human Papillomavirus Type 11 E1E2 ProteinProtein Interaction
✍ Christiane Yoakim; Nathalie Goudreau; Graham A. McGibbon; Jeff O'Meara; Peter W. 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 German ⚖ 262 KB

## Abstract A novel series of inhibitors of the HPV11 E1E2 proteinprotein interaction was identified. These inhibitors, which were discovered as a result of high‐throughput screening, feature an indandione system spiro‐fused onto an appropriately substituted tetrahydrofuran ring. Early stability