Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure–activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1

✍ Scribed by Sifferlen, Thierry; Boller, Amandine; Chardonneau, Audrey; Cottreel, Emmanuelle; Hoecker, Johannes; Aissaoui, Hamed; Williams, Jodi T.; Brotschi, Christine; Heidmann, Bibia; Siegrist, Romain; Gatfield, John; Treiber, Alexander; Brisbare-Roch, Catherine; Jenck, Francois; Boss, Christoph

• Book ID: 121499178
• Publisher: Elsevier Science
• Year: 2014
• Tongue: English
• Weight: 951 KB
• Volume: 24
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2013.12.092