✦ LIBER ✦

Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy

✍ Scribed by Kempf, Dale J.; Sham, Hing L.; Marsh, Kennan C.; Flentge, Charles A.; Betebenner, David; Green, Brian E.; McDonald, Edith; Vasavanonda, Sudthida; Saldivar, Ayda; Wideburg, Norman E.; Kati, Warren M.; Ruiz, Lisa; Zhao, Chen; Fino, LynnMarie; Patterson, Jean; Molla, Akhteruzzaman; Plattner, Jacob J.; Norbeck, Daniel W.

Book ID: 119978936
Publisher: American Chemical Society
Year: 1998
Tongue: English
Weight: 189 KB
Volume: 41
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm970636+

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: Discovery of Ritona

ChemInform Abstract: Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy.

✍ D. J. KEMPF; ET AL. ET AL. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Potent Inhibitors of the HIV-1 Protease

Potent Inhibitors of the HIV-1 Protease with Good Oral Bioavailabilities

✍ H.L. Sham; C. Zhao; K.C. Marsh; D.A. Betebenner; S.Q. Lin; E. Mcdonald; S. Vasav 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 315 KB

Structure-based discovery of tipranavir

Structure-based discovery of tipranavir disodium (PNU-140690E): A potent, orally bioavailable, nonpeptidic HIV protease inhibitor

✍ Suvit Thaisrivongs; Joseph W. Strohbach 📂 Article 📅 1999 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 167 KB 👁 1 views

Efforts to develop therapeutically relevant HIV protease inhibitors as medicinal agents in confronting the AIDS crisis have been aided by the wealth of fundamental information acquired during related drug discovery campaigns against other aspartyl proteases. This knowledge base was brought to full f

Viracept (Nelfinavir Mesylate, AG1343):

Viracept (Nelfinavir Mesylate, AG1343): A Potent, Orally Bioavailable Inhibitor of HIV-1 Protease

✍ Kaldor, Stephen W.; Kalish, Vincent J.; Davies, Jay F.; Shetty, Bhasker V.; Frit 📂 Article 📅 1997 🏛 American Chemical Society 🌐 English ⚖ 257 KB

Discovery of PF-04449913, a Potent and O

Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened

✍ Munchhof, Michael J.; Li, Qifang; Shavnya, Andrei; Borzillo, Gary V.; Boyden, Tr 📂 Article 📅 2011 🏛 American Chemical Society 🌐 English ⚖ 721 KB

A new hydroxyethylamine class of HIV-1 p

A new hydroxyethylamine class of HIV-1 protease inhibitors with high antiviral potency and oral bioavailability

✍ B.Moon Kim; Joseph P. Vacca; James P. Guare; Colleen M. Hanifin; Stuart R. Miche 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 463 KB

A new hydroxyethylamine class of inhibitors was designed combining features from our clinical candidate, L-735.524, along with small heterocvclic PGaands develoDed in these laboratories. Hiahlv notent inhibitors possessing sub&omolar IC5O's have beenid&ified, whi<h exhibit good antiviral pott& h cel