Discovery of ( R )-1-(7-Chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): A Temperature-Neutral Transient Receptor Potential Vanilloid-1 (TRPV1) Antagonist with Analgesic Efficacy

✍ Scribed by Voight, Eric A.; Gomtsyan, Arthur R.; Daanen, Jerome F.; Perner, Richard J.; Schmidt, Robert G.; Bayburt, Erol K.; DiDomenico, Stanley; McDonald, Heath A.; Puttfarcken, Pamela S.; Chen, Jun; Neelands, Torben R.; Bianchi, Bruce R.; Han, Ping; Reilly, Regina M.; Franklin, Pamela H.; Segreti, Jason A.; Nelson, Richard A.; Su, Zhi; King, Andrew J.; Polakowski, James S.; Baker, Scott J.; Gauvin, Donna M.; Lewis, LaGeisha R.; Mikusa, Joseph P.; Joshi, Shailen K.; Faltynek, Connie R.; Kym, Philip R.; Kort, Michael E.

• Book ID: 126972202
• Publisher: American Chemical Society
• Year: 2014
• Tongue: English
• Weight: 944 KB
• Volume: 57
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm500916t