Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: Optimization studies and demonstration of in vivo efficacy

✍ Scribed by Plummer, Mark S.; Cornicelli, Joseph; Roark, Howard; Skalitzky, Donald J.; Stankovic, Charles J.; Bove, Susan; Pandit, Jayvardhan; Goodman, Annise; Hicks, James; Shahripour, Aurash; Beidler, David; Lu, Xiao Kang; Sanchez, Brian; Whitehead, Christopher; Sarver, Ron; Braden, Timothy; Gowan, Richard; Shen, Xi Qiang; Welch, Katherine; Ogden, Adam; Sadagopan, Nalini; Baum, Heidi; Miller, Howard; Banotai, Craig; Spessard, Cindy; Lightle, Sandra

• Book ID: 120344129
• Publisher: Elsevier Science
• Year: 2013
• Tongue: English
• Weight: 1007 KB
• Volume: 23
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2013.03.082