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Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase

✍ Scribed by Sandra Gemma; Stefania Butini; Giuseppe Campiani; Margherita Brindisi; Samantha Zanoli; Maria Pia Romano; Pierangela Tripaldi; Luisa Savini; Isabella Fiorini; Giuseppe Borrelli; Ettore Novellino; Giovanni Maga


Book ID
104004864
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
593 KB
Volume
21
Category
Article
ISSN
0960-894X

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## Abstract The hepatitis C virus (HCV) nonstructural 3 (NS3) protein is composed of an amino terminal protease and a carboxyl terminal RNA helicase. NS3 contains major antigenic epitopes. The antibody response to NS3 appears early in the course of infection and is focused on the helicase region. H