✦ LIBER ✦

Discovery of Orally Efficacious Tetracyclic Metabotropic Glutamate Receptor 1 (mGluR1) Antagonists for the Treatment of Chronic Pain

✍ Scribed by Wu, Wen-Lian; Burnett, Duane A.; Domalski, Martin; Greenlee, William J.; Li, Cheng; Bertorelli, Rosalia; Fredduzzi, Silva; Lozza, Gianluca; Veltri, Alessio; Reggiani, Angelo

Book ID: 127083087
Publisher: American Chemical Society
Year: 2007
Tongue: English
Weight: 82 KB
Volume: 50
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm070590c

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Prospects for Metabotropic Glutamate 1 R

Prospects for Metabotropic Glutamate 1 Receptor Antagonists in the Treatment of Neuropathic Pain.

✍ Jeffrey M. Schkeryantz; Ann E. Kingston; Michael P. Johnson 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 11 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Knockdown of spinal metabotropic glutama

Knockdown of spinal metabotropic glutamate receptor 1 (mGluR1) alleviates pain and restores opioid efficacy after nerve injury in rats

✍ Marian E Fundytus; Kiran Yashpal; Jean-Guy Chabot; Michael G Osborne; Celeste D 📂 Article 📅 2001 🏛 Nature Publishing Group 🌐 English ⚖ 547 KB

Fused tricyclic mGluR1 antagonists for t

Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain

✍ Chad E. Bennett; Duane A. Burnett; William J. Greenlee; Chad E. Knutson; Peter K 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 877 KB

Antinociceptive profile of a selective m

Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models

✍ Atsuyuki Kohara; Yukinori Nagakura; Tetsuo Kiso; Takashi Toya; Tomonari Watabiki 📂 Article 📅 2007 🏛 Elsevier Science 🌐 English ⚖ 399 KB

A New Binding Mode of Competitive Antago

A New Binding Mode of Competitive Antagonists to Metabotropic Glutamate Receptors Exemplified by the mGluR1-Receptor Antagonist AIDA (RS-Aminoindan-1,5-Dicarboxylic Acid)

✍ M. S. Belenikin; I. I. Baskin; V. A. Palyulin; N. S. Zefirov 📂 Article 📅 2002 🏛 SP MAIK Nauka/Interperiodica 🌐 English ⚖ 447 KB

Global physicochemical properties as act

Global physicochemical properties as activity discriminants for the mGluR1 subtype of metabotropic glutamate receptors

✍ Marta Filizola; Silvina M. Tasso; Gilda H. Loew; Hugo O. Villar 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 182 KB

## Abstract Metabotropic glutamate receptors (mGluRs) are important as candidate therapeutic targets for many neurological disorders. In the present work, the focus has been on the mGluR1 subtype, where agonists have a proconvulsant profile while antagonists exert anticonvulsant activity. Identific