Discovery of Novel Dialkyl Substituted Thiophene Inhibitors of HCV by in silico Screening of the NS5B RdRp.

The Discovery of Pyrano[3,4-b]indole-Bas

The Discovery of Pyrano[3,4-b]indole-Based Allosteric Inhibitors of HCV NS5B Polymerase with In Vivo Activity

✍ Matthew G. LaPorte; Randy W. Jackson; Tandy L. Draper; Janet A. Gaboury; Kristin 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 354 KB

Hepatitis C (HCV) belongs to the Flaviviridae family of positivesense, single-stranded RNA viruses. The HCV genome encodes a polyprotein, comprised of 3000 amino acid residues, which is processed into both structural and nonstructural proteins. [1] HCV infection is a significant global health issue;