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Discovery of N-benzyl-N′-(4-pipyridinyl)urea CCR5 antagonists as anti-HIV-1 agents (I): Optimization of the amine portion

✍ Scribed by Maosheng Duan; Jennifer Peckham; Mark Edelstein; Robert Ferris; Wieslaw M. Kazmierski; Andrew Spaltenstein; Pat Wheelan; Zhiping Xiong


Book ID
104004997
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
380 KB
Volume
20
Category
Article
ISSN
0960-894X

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Discovery of N-benzyl-N′-(4-pipyridinyl)
✍ Maosheng Duan; Jennifer Peckham; Mark Edelstein; Robert Ferris; Wieslaw M. Kazmi 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 255 KB

Modification of the acyl moiety in the CCR5 lead molecule 2 led to identification of several new classes of CCR5 antagonists. Antiviral activity and pharmacokinetic properties of the synthesized compounds were evaluated. Structure-activity relationship (SAR) derived from these studies further guided