Discovery of N-benzyl-N′-(4-pipyridinyl)
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Maosheng Duan; Jennifer Peckham; Mark Edelstein; Robert Ferris; Wieslaw M. Kazmi
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Article
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2010
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Elsevier Science
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English
⚖ 255 KB
Modification of the acyl moiety in the CCR5 lead molecule 2 led to identification of several new classes of CCR5 antagonists. Antiviral activity and pharmacokinetic properties of the synthesized compounds were evaluated. Structure-activity relationship (SAR) derived from these studies further guided