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Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists

✍ Scribed by Christopher A. Luckhurst; Linda A. Stein; Mark Furber; Nicola Webb; Marianne J. Ratcliffe; Gary Allenby; Sara Botterell; Wendy Tomlinson; Barrie Martin; Andrew Walding


Book ID
104005064
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
648 KB
Volume
21
Category
Article
ISSN
0960-894X

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Discovery of tetrahydroisoquinoline (THI
✍ Min Zhong; Wang Shen; Kenneth J. Barr; Jennifer P. Arbitrario; Michelle R. Arkin 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 600 KB

This letter describes the discovery of a novel series of tetrahydroisoquinoline (THIQ)-derived small molecules that potently inhibit both human T-cell migration and super-antigen induced T-cell activation through disruption of the binding of integrin LFA-1 to its receptor, ICAM-1. In addition to exc