Discovery of Inhibitors of Human Adipocyte Fatty Acid-Binding Protein, a Potential Type 2 Diabetes Target.

A rare missense mutation in a type 2 dia

A rare missense mutation in a type 2 diabetes patient decreases the transcriptional activity of human sterol regulatory element binding protein-1

✍ Santiago Vernia; Delphine Eberlé; Antonio Hernandez Mijares; Fabienne Foufelle; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 196 KB

Sterol regulatory element binding protein 1 (SREBP-1) transcription factors play a key role in energy homeostasis by regulating genes involved in both carbohydrate and lipid metabolism, and in adipocyte differentiation. The 5' end of the mRNA-encoding SREBP-1 exists in two forms, designated 1a and 1