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Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the β-ketoacyl reductase reaction

✍ Scribed by María Jesús Vázquez; William Leavens; Ronggang Liu; Beatriz Rodríguez; Martin Read; Stephen Richards; Deborah Winegar; Juan Manuel Domínguez


Book ID
111312335
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
405 KB
Volume
275
Category
Article
ISSN
1432-1327

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The role of P-ketoacyl-ACP synthases (condensing enzymes, KAS) in the regulation of the biosynthesis of medium-chain fatty acids in Cuphea lanceolata seed (86.5% decanoic acid in oil) was investigated. KAS I11 catalyzes the first condensing step of fatty acid synthase (FAS) reaction between acetyl-C