Structures containing the (R)-3-amino-3-methyl piperidine unit as a new pharmacophore moiety have been shown to possess moderate inhibitory activity for DPP-4 with good pharmacokinetics profile. One of these compounds was found to have good oral bioavailability and PK/PD profile in ZF-rat.
β¦ LIBER β¦
Discovery of dual function acridones as a new antimalarial chemotype
β Scribed by Kelly, Jane X.; Smilkstein, Martin J.; Brun, Reto; Wittlin, Sergio; Cooper, Roland A.; Lane, Kristin D.; Janowsky, Aaron; Johnson, Robert A.; Dodean, Rozalia A.; Winter, Rolf
- Book ID
- 109898120
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 251 KB
- Volume
- 459
- Category
- Article
- ISSN
- 0028-0836
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