Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists
โ Scribed by Christopher Sinz; Jiang Chang; Ashley Rouse Lins; Ed Brady; Mari Candelore; Qing Dallas-Yang; Victor Ding; Guoqiang Jiang; Zhen Lin; Steven Mock; Sajjad Qureshi; Gino Salituro; Richard Saperstein; Jackie Shang; Deborah Szalkowski; Laurie Tota; Stella Vincent; Michael Wright; Shiyao Xu; Xiaodong Yang; Bei Zhang; James Tata; Ronald Kim; Emma Parmee
- Book ID
- 113496211
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 492 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A novel class of 1,3,5-pyrazoles has been discovered as potent human glucagon receptor antagonists. Notably, compound 26 is orally bioavailable in several preclinical species and shows selectivity towards cardiac ion channels, other family B receptors such hGIP and hGLP1, and a large panel of enzyme