Discovery of Aminopyridine-Based Inhibitors of Bacterial Enoyl-ACP Reductase (FabI)
β Scribed by Miller, William H.; Seefeld, Mark A.; Newlander, Kenneth A.; Uzinskas, Irene N.; Burgess, Walter J.; Heerding, Dirk A.; Yuan, Catherine C. K.; Head, Martha S.; Payne, David J.; Rittenhouse, Stephen F.; Moore, Terrance D.; Pearson, Stewart C.; Berry, Valerie; DeWolf, Walter E.; Keller, Paul M.; Polizzi, Brian J.; Qiu, Xiayang; Janson, Cheryl A.; Huffman, William F.
- Book ID
- 119978904
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 181 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0022-2623
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## Abstract Benzothiophene derivatives like benzothiophene sulphonamides, biphenyls, or carboxyls have been synthesized and have found wide pharmacological usage. Here we report, bromoβbenzothiophene carboxamide derivatives as potent, slow tight binding inhibitors of __Plasmodium__ enoylβacyl carri