Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on an N,N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats

✍ Scribed by David B. Whitman; Christopher D. Cox; Michael J. Breslin; Karen M. Brashear; John D. Schreier; Michael J. Bogusky; Rodney A. Bednar; Wei Lemaire; Joseph G. Bruno; George D. Hartman; Duane R. Reiss ; C. Meacham Harrell; Richard L. Kraus; Yuxing Li; Susan L. Garson; Scott M. Doran; Thomayant Prueksaritanont; Chunze Li; Christopher J. Winrow; Kenneth S. Koblan; John J. Renger; Paul J. Coleman

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 418 KB
• Volume: 4
• Category: Article
• ISSN: 1860-7179
• DOI: 10.1002/cmdc.200900069