Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905)

✍ Scribed by Duffey, Matthew O.; Vos, Tricia J.; Adams, Ruth; Alley, Jennifer; Anthony, Justin; Barrett, Cynthia; Bharathan, Indu; Bowman, Douglas; Bump, Nancy J.; Chau, Ryan; Cullis, Courtney; Driscoll, Denise L.; Elder, Amy; Forsyth, Nancy; Frazer, Jonathan; Guo, Jianping; Guo, Luyi; Hyer, Marc L.; Janowick, David; Kulkarni, Bheemashankar; Lai, Su-Jen; Lasky, Kerri; Li, Gang; Li, Jing; Liao, Debra; Little, Jeremy; Peng, Bo; Qian, Mark G.; Reynolds, Dominic J.; Rezaei, Mansoureh; Scott, Margaret Porter; Sells, Todd B.; Shinde, Vaishali; Shi, Qiuju Judy; Sintchak, Michael D.; Soucy, Francois; Sprott, Kevin T.; Stroud, Stephen G.; Nestor, Michelle; Visiers, Irache; Weatherhead, Gabriel; Ye, Yingchun; D’Amore, Natalie

• Book ID: 118125556
• Publisher: American Chemical Society
• Year: 2011
• Tongue: English
• Weight: 467 KB
• Volume: 55
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm2011172