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Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors

โœ Scribed by Lee, Kyeong; Goo, Ja-Il; Jung, Hwa Young; Kim, Minkyoung; Boovanahalli, Shanthaveerappa K.; Park, Hye Ran; Kim, Mun-Ock; Kim, Dong-Hyun; Lee, Hyun Sun; Choi, Yongseok


Book ID
120488961
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
391 KB
Volume
22
Category
Article
ISSN
0960-894X

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Acyl-CoA:cholesterol acyltransferase (E.C.2.3.1.26, ACAT) is a microsomial enzyme that catalyses the formation of cholesteryl esters by acylation of cholesterol with long chain fatty acylCoA [1]. ACAT plays important roles in cellular homeostasis and in the early stages of atherosclerosis. Therefor