✦ LIBER ✦

Discovery of a Novel Class of Potent and Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists

✍ Scribed by Ibrahim, Mohamed A.; Johnson, Henry W. B.; Jeong, Joon Won; Lewis, Gary L.; Shi, Xian; Noguchi, Robin T.; Williams, Matthew; Leahy, James W.; Nuss, John M.; Woolfrey, John; Banica, Monica; Bentzien, Frauke; Chou, Yu-Chien; Gibson, Anna; Heald, Nathan; Lamb, Peter; Mattheakis, Larry; Matthews, David; Shipway, Aaron; Wu, Xiang; Zhang, WenTao; Zhou, Sihong; Shankar, Geetha

Book ID: 118022978
Publisher: American Chemical Society
Year: 2012
Tongue: English
Weight: 108 KB
Volume: 55
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm201533b

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Discovery of Orally Bioavailable NK1 Rec

Discovery of Orally Bioavailable NK1 Receptor Antagonists.

✍ C. Genicot; et al. et al. 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 15 KB 👁 2 views

Discovery of Novel 1,2,4-Thiadiazole Der

Discovery of Novel 1,2,4-Thiadiazole Derivatives as Potent, Orally Active Agonists of Sphingosine 1-Phosphate Receptor Subtype 1 (S1P1)

✍ Ren, Feng; Deng, Guanghui; Wang, Hailong; Luan, Linbo; Meng, Qinghua; Xu, Qiongf 📂 Article 📅 2012 🏛 American Chemical Society 🌐 English ⚖ 856 KB

Discovery of tetrahydroisoquinoline (THI

Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists

✍ Min Zhong; Wang Shen; Kenneth J. Barr; Jennifer P. Arbitrario; Michelle R. Arkin 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 600 KB

This letter describes the discovery of a novel series of tetrahydroisoquinoline (THIQ)-derived small molecules that potently inhibit both human T-cell migration and super-antigen induced T-cell activation through disruption of the binding of integrin LFA-1 to its receptor, ICAM-1. In addition to exc

Potent and Orally Bioavailable 8-Bicyclo

Potent and Orally Bioavailable 8-Bicyclo[2.2.2]octylxanthines as Adenosine A 1 Receptor Antagonists

✍ Kiesman, William F.; Zhao, Jin; Conlon, Patrick R.; Dowling, James E.; Petter, R 📂 Article 📅 2006 🏛 American Chemical Society 🌐 English ⚖ 220 KB

Discovery of Potent Orally Active Thromb

Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents

✍ Chackalamannil, Samuel; Xia, Yan; Greenlee, William J.; Clasby, Martin; Doller, 📂 Article 📅 2005 🏛 American Chemical Society 🌐 English ⚖ 88 KB

Hit-to-Lead Studies: The Discovery of Po

Hit-to-Lead Studies: The Discovery of Potent, Orally Bioavailable Thiazolopyrimidine CXCR2 Receptor Antagonists.

✍ Andrew Baxter; Anne Cooper; Elizabeth Kinchin; Kerry Moakes; John Unitt; Alan Wa 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 12 KB 👁 2 views