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Discovery of a Novel Chemotype of Tyrosine Kinase Inhibitors by Fragment-Based Docking and Molecular Dynamics

✍ Scribed by Zhao, Hongtao; Dong, Jing; Lafleur, Karine; Nevado, Cristina; Caflisch, Amedeo


Book ID
115458908
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
335 KB
Volume
3
Category
Article
ISSN
1948-5875

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Bruton’s tyrosine kinase has emerged as a potential target for the treatment for B‐cell malignancies and autoimmune diseases. Discovery of Bruton’s tyrosine kinase inhibitors has thus attracted much attention recently. In this investigation, we introduced a hybrid protocol of virtual screening metho