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Discovery of 4-Morpholino-6-aryl-1 H -pyrazolo[3,4- d ]pyrimidines as Highly Potent and Selective ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR): Optimization of the 6-Aryl Substituent

✍ Scribed by Verheijen, Jeroen C.; Richard, David J.; Curran, Kevin; Kaplan, Joshua; Lefever, Mark; Nowak, Pawel; Malwitz, David J.; Brooijmans, Natasja; Toral-Barza, Lourdes; Zhang, Wei-Guo; Lucas, Judy; Hollander, Irwin; Ayral-Kaloustian, Semiramis; Mansour, Tarek S.; Yu, Ker; Zask, Arie

Book ID: 118237465
Publisher: American Chemical Society
Year: 2009
Tongue: English
Weight: 161 KB
Volume: 52
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm9013828

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ChemInform Abstract: Pyrazolopyrimidines

ChemInform Abstract: Pyrazolopyrimidines as Highly Potent and Selective, ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR): Optimization of the 1-Substituent.

✍ Kevin J. Curran; Jeroen C. Verheijen; Joshua Kaplan; David J. Richard; Lourdes T 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 19 KB

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