✦ LIBER ✦
Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-Based Hight-Throughput Screening Assay. Part 2. Structure—Activity Relationships of the 7- and 5-, 6-, 8-Positions.
✍ Scribed by Sui Xiong Cai; et al. et al.
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 14 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
✦ Synopsis
Medicinal chemistry V 1100 Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell-and Caspase-Based Hight-Throughput Screening Assay. Part 2. Structure-Activity Relationships of the 7-and 5-, 6-, 8-Positions. -The structure-activity relationships of novel derivatives such as (I) are discussed. Small hydrophobic groups at the 7-position are preferred and disubstitution at 7,8-position, cf. derivatives (Ic) and (Id), results in potent compounds. -(CAI*, S. X.; et al.; Bioorg.