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Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators

✍ Scribed by Guo, Chuangxing; Linton, Angelica; Jalaie, Mehran; Kephart, Susan; Ornelas, Martha; Pairish, Mason; Greasley, Samantha; Richardson, Paul; Maegley, Karen; Hickey, Michael; Li, John; Wu, Xin; Ji, Xiaodong; Xie, Zhi


Book ID
120159122
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
831 KB
Volume
23
Category
Article
ISSN
0960-894X

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✍ Yıldırım, Sema Öztürk ;Akkurt, Mehmet ;Önal, Zülbiye ;Büyükgüngör, Orhan 📂 Article 📅 2007 🏛 International Union of Crystallography 🌐 English ⚖ 145 KB

Molecules of the title compound, C 27 H 23 N 3 O 2 , contain four rings that are not coplanar and the pyrimidine ring is slightly distorted from planarity. The dihedral angles between pairs of benzene rings are 88.6 (1), 88.6 (1) and 62.9 (1) . The three benzene rings form dihedral angles of 55.3 (1