Development of 2-pyrrolidinyl-N-methyl p
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Marco Ferrara; Fabrizio Fiore; Vincenzo Summa; Cristina Gardelli
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Article
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2010
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Elsevier Science
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English
β 524 KB
A series of 2-pyrrolidinyl-N-methyl pyrimidones HIV integrase inhibitors has been explored leading to the identification of derivative 13, which showed high activity at inhibiting viral replication in cell culture, favorable pharmacokinetic profile in two preclinical species, and an attractive profi