Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents
✍ Scribed by Draffan, Alistair G.; Frey, Barbara; Pool, Brett; Gannon, Carlie; Tyndall, Edward M.; Lilly, Michael; Francom, Paula; Hufton, Richard; Halim, Rosliana; Jahangiri, Saba; Bond, Silas; Nguyen, Van T. T.; Jeynes, Tyrone P.; Wirth, Veronika; Luttick, Angela; Tilmanis, Danielle; Thomas, Jesse D.; Pryor, Melinda; Porter, Kate; Morton, Craig J.; Lin, Bo; Duan, Jianmin; Kukolj, George; Simoneau, Bruno; McKercher, Ginette; Lagacé, Lisette; Amad, Ma’an; Bethell, Richard C.; Tucker, Simon P.
- Book ID
- 124075441
- Publisher
- American Chemical Society
- Year
- 2014
- Tongue
- English
- Weight
- 396 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1948-5875
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## Abstract The title compounds, e.g. (XI) exhibit no activity or cytotoxicity in the HCV (hepatitis‐C virus) assay.
The electron-impact (EI) mass spectrometric behaviour of a series of 8-aza-purines derivatized with hydroxymethylcyclopentane and exhibiting cis-trans isomerization in the cyclopentane ring has been studied in detail with the aid of metastable-ion data. Specific fragmentation processes, present in b