Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation

✍ Scribed by Shaun R. Stauffer; Matthew G. Stanton; Alison R. Gregro; Melissa A. Steinbeiser; Jennifer R. Shaffer; Philippe G. Nantermet; James C. Barrow; Kenneth E. Rittle; Dennis Collusi; Amy S. Espeseth; Ming-Tain Lai; Beth L. Pietrak; M. Katharine Holloway; Georgia B. McGaughey; Sanjeev K. Munshi; Jerome H. Hochman; Adam J. Simon; Harold G. Selnick; Samuel L. Graham; Joseph P. Vacca

• Book ID: 108074250
• Publisher: Elsevier Science
• Year: 2007
• Tongue: English
• Weight: 281 KB
• Volume: 17
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2006.12.051