Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist
β Scribed by Angus R. Brown; Michael Bosies; Helen Cameron; John Clark; Angela Cowley; Mark Craighead; Moira A. Elmore; Alistair Firth; Richard Goodwin; Susan Goutcher; Emma Grant; Morag Grassie; Simon J.A. Grove; Niall M. Hamilton; Hannah Hampson; Alison Hillier; Koc-Kan Ho; Michael Kiczun; Celia Kingsbury; Steven G. Kultgen; Peter T.A. Littlewood; Scott J. Lusher; Susan MacDonald; Lorraine McIntosh; Theresa McIntyre; Ashvin Mistry; J. Richard Morphy; Olaf Nimz; Michael Ohlmeyer; Jack Pick; Zoran Rankovic; Brad Sherborne; Alasdair Smith; Michael Speake; Gayle Spinks; Fiona Thomson; Lynn Watson; Mark Weston
- Book ID
- 104005127
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 374 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0960-894X
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
## Abstract We demonstrated the synthesis of carbonβ11 labeled 17β__Ξ±__βhydroxyβ11β__Ξ²__β/4β/[methyl]β[1βmethylethyl]βaminophenyl/β17__Ξ±__β[propβ1βynyl]estaβ4β9βdieneβ3βone (RU40555), a selective glucocorticoid receptor (GR) antagonist, and examined the __in vivo__ profile of [^11^C]RU40555. [^11^