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Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist

✍ Scribed by Angus R. Brown; Michael Bosies; Helen Cameron; John Clark; Angela Cowley; Mark Craighead; Moira A. Elmore; Alistair Firth; Richard Goodwin; Susan Goutcher; Emma Grant; Morag Grassie; Simon J.A. Grove; Niall M. Hamilton; Hannah Hampson; Alison Hillier; Koc-Kan Ho; Michael Kiczun; Celia Kingsbury; Steven G. Kultgen; Peter T.A. Littlewood; Scott J. Lusher; Susan MacDonald; Lorraine McIntosh; Theresa McIntyre; Ashvin Mistry; J. Richard Morphy; Olaf Nimz; Michael Ohlmeyer; Jack Pick; Zoran Rankovic; Brad Sherborne; Alasdair Smith; Michael Speake; Gayle Spinks; Fiona Thomson; Lynn Watson; Mark Weston


Book ID
104005127
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
374 KB
Volume
21
Category
Article
ISSN
0960-894X

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Synthesis and evaluation of [11C]RU40555
✍ Takahiro Matsuya; Hiroyuki Takamatsu; Yoshihiro Murakami; Akihiro Noda; Kazuhiko πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 French βš– 224 KB

## Abstract We demonstrated the synthesis of carbon‐11 labeled 17‐__Ξ±__‐hydroxy‐11‐__Ξ²__‐/4‐/[methyl]‐[1‐methylethyl]‐aminophenyl/‐17__Ξ±__‐[prop‐1‐ynyl]esta‐4‐9‐diene‐3‐one (RU40555), a selective glucocorticoid receptor (GR) antagonist, and examined the __in vivo__ profile of [^11^C]RU40555. [^11^