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Discovery and development of clofarabine: a nucleoside analogue for treating cancer

✍ Scribed by Bonate, Peter L.; Arthaud, Larry; Cantrell, William R.; Stephenson, Katherine; Secrist, John A.; Weitman, Steve

Book ID
109950074
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
549 KB
Volume
5
Category
Article
ISSN
1474-1776

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## Abstract Clofarabine is a new‐generation nucleoside analog that has been synthesized to combine the most favorable pharmacokinetic properties of its congeners fludarabine and cladribine. In addition to inhibition of DNA polymerases and DNA synthesis, clofarabine acts as a strong inhibitor of rib