Discovery and antibacterial activity of lucensimycin C from Streptomyces lucensis

✍ Scribed by Sheo B. Singh; Deborah L. Zink; Kithsiri B. Herath; Oscar Salazar; Olga Genilloud

• Book ID: 104095113
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 116 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.02.092

✦ Synopsis

Protein synthesis is one of the key and validated antibacterial targets and its inhibition has led to the development of highly successful clinical drugs. Ribosomal protein S4 (RPSD) is a part of ribosomal machinery and a new potential target for antibacterial agents. Screening of microbial extracts using antisense sensitized rpsD strain in Staphylococcus aureus followed by chemical analysis led to the isolation of a new compound lucensimycin C, which is a key biosynthetic intermediate of the other lucensimycins. Isolation, structure elucidation, antibiotic activity, and biogenesis have been described.