β Scribed by Tzu-Chien V. Wang
No coin nor oath required. For personal study only.
The postulate that a stalled/collapsed replication fork will be generated when the replication complex encounters a UVβinduced lesion in the template for leadingβstrand DNA synthesis is based on the model of semiβdiscontinuous DNA replication. A review of existing data indicates that the semiβdiscontinuous DNA replication model is supported by data from in vitro studies, while the discontinuous DNA replication model is supported by in vivo studies in Escherichia coli. Until the question of whether DNA replicates discontinuously in one or both strands is clearly resolved, any model building based on either one of the two DNA replication models should be treated with caution. BioEssays 27:633β636, 2005. Β© 2005 Wiley Periodicals, Inc.
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