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Discontinuous absorption processes in pharmacokinetic models

✍ Scribed by Richard Süverkrüp

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
609 KB
Volume
68
Category
Article
ISSN
0022-3549

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✦ Synopsis

The limited contact time of absorbable drug with absorbing surfaces is, in some cases, a significant factor determining the fraction of the dose absorbed. A simple modification of customary linear compartmental models is presented to account for this situation, and a general input function in the Laplace domain for truncated first-order absorption is derived. An extension to series of truncated absorption processes is discussed.

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