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Discodermolide interferes with the binding of tau protein to microtubules

✍ Scribed by Santwana Kar; Gordon J Florence; Ian Paterson; Linda A Amos


Book ID
117105204
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
189 KB
Volume
539
Category
Article
ISSN
0014-5793

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Previous studies have demonstrated that the microtubule-associated proteins MAP-2 and tau interact selectively with common binding domains on tubulin defined by the low-homology segments alpha (430-441) and beta (422-434). It has been also indicated that the synthetic peptide VRSKIGSTENLKHQPGGG corr