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Disappearance of the Epstein-Barr virus in a relapse of Hodgkin's disease

โœ Scribed by Delecluse, Henri-Jacques; Marafioti, Teresa; Hummel, Michael; Dallenbach, Friederike; Anagnostopoulos, Ioannis; Stein, Harald

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
848 KB
Volume
182
Category
Article
ISSN
0022-3417

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โœฆ Synopsis

Hodgkin's disease (HD) is associated with the Epstein-Barr virus (EBV) in approximately half of cases. This is a report of a case of nodular sclerosing HD of the B-cell type that was associated with EBV in the initial manifestation, but was found to be EBV-negative in the relapse of the tumour. Both tumours displayed similar clinical, pathological, and immunohistochemical features. This finding implies that in a given individual EBV can be lost from malignant tumours and therefore shows that the EBV infection is not required to maintain neoplastic growth of HD tumour cells. 1997 by John Wiley & Sons, Ltd.

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