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Direction of cyclization in the Fischer indole synthesis. Mechanistic considerations

✍ Scribed by Miller, F. M.; Schinske, W. Neal


Book ID
120975389
Publisher
American Chemical Society
Year
1978
Tongue
English
Weight
583 KB
Volume
43
Category
Article
ISSN
0022-3263

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πŸ“œ SIMILAR VOLUMES


The cyclization phase of the fischer ind
✍ Richard J. Owellen; James A. Fitzgerald; Berenice M. Fitzgerald; David A. Welsh; πŸ“‚ Article πŸ“… 1967 πŸ› Elsevier Science 🌐 French βš– 300 KB

Plieninger (1) reported that the phenywdrazone of a-keto-y-butyrolactone (I), when subjected to the conditions appropriate for the Fischer indole synthesis (treatment with hydrogen chloride in glacial acetic acid at 900), rearranged to form a product for which the structure 11 was suggested. The lat