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Directed MetalationCross-Coupling Strategies. Total Syntheses of the Alleged and the Revised Phenanthrene Natural Product Gymnopusin

✍ Scribed by Wang, Xin; Fu, Jian-min; Snieckus, Victor


Book ID
118233769
Publisher
John Wiley and Sons
Year
2012
Tongue
German
Weight
260 KB
Volume
95
Category
Article
ISSN
0018-019X

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Synthetic strategies based on aromatic m
✍ X. Wang; V. Snieckus 📂 Article 📅 1991 🏛 Elsevier Science 🌐 French ⚖ 126 KB

An efficient synthesis of gymnopusin (2) using ortho metalation, Suzuki cross coupling, and new anionic Fries rearrangement (3) steps has been achieved. Gymnopusin, an unusual C-9(-10)-oxygenated phenanthrene isolated from Bulbophyllum gymnopus (Orchidaceae) was originally assigned structure 1,1 bu