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Directed Evolution of a Soluble Human IL-17A Receptor for the Inhibition of Psoriasis Plaque Formation in a Mouse Model

โœ Scribed by Zaretsky, Marianna; Etzyoni, Revital; Kaye, Joel; Sklair-Tavron, Liora; Aharoni, Amir


Book ID
121322679
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
608 KB
Volume
20
Category
Article
ISSN
1074-5521

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## Abstract ## Background Geneโ€directed enzyme prodrug therapy (GDEPT) based on the __E. coli__ enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed enzyme converts a systemically administered prodrug, fludar